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Aging of the population and increasing prevalence of obesity are associated with the increasing prevalence of knee OA, which has become a worldwide problem. Therefore, the need for efficacious, reliable and cost-effective treatment modalities have been emphasized. Treatment modalities for knee OA include non-pharmacological interventions (education, exercising, orthotic prescriptions, electrotherapy), pharmacological therapies (paracetamol, non-steroidal anti-inflammatory drugs [NSAIDs], topical agents and chondroprotective drugs), non-surgical procedures (intra-articular steroid and hyaluronic acid injections, platelet-rich plasma [PRP], acupuncture) and surgical interventions (arthroscopy, arthroplasty). However, in spite of all these treatment modalities, adequate pain control may not be achieved in patients with knee OA [1,2].
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