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Osteoarthritis, a condition commonly associated with aging, has long been attributed to joint “wear and tear,” often blamed on activities like running. It turns out this isn’t always true. Research has shed light on the complex biological factors that contribute to the development of osteoarthritis. By exploring these underlying mechanisms and examining the role of metabolic health, prior injury, cellular responses, macrophage ‘polarization,’ and biomarkers such as IL6 and COMP, we can start to dispel the misconception that osteoarthritis is solely caused by mechanical strain.
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